NPS receptor (npsr1_human)
FAMILY
Class A (Rhodopsin) Peptide receptors Neuropeptide S receptors NPS receptor
GENE
NPSR1 (GPR154, GPRA, PGR14)
ORGANISM
Human (Homo sapiens)
ALT. NAMES
Neuropeptide S receptor, G-protein coupled receptor 154, G-protein coupled receptor PGR14, G-protein coupled receptor for asthma susceptibility
SOURCE
SWISSPROT
SEQUENCE
N-term | |||||||||
M
|
P
|
A
|
N
|
F
|
T
|
E
|
G
|
S
|
F
|
10 |
D
|
S
|
S
|
G
|
T
|
G
|
Q
|
T
|
L
|
D
|
20 |
S
|
S
|
P
|
V
|
A
|
C
|
T
|
E
|
T
|
V
|
30 |
T
|
F
|
T
|
E
|
V
|
V
|
E
|
G
|
K
|
E
|
40 |
TM1 | |||||||||
W
|
G
|
S
|
F
|
Y
|
Y
|
S
|
F
|
K
|
T
|
50 |
E
|
Q
|
L
|
I
|
T
|
L
|
W
|
V
|
L
|
F
|
60 |
V
|
F
|
T
|
I
|
V
|
G
|
N
|
S
|
V
|
V
|
70 |
L
|
F
|
S
|
T
|
W
|
R
|
R
|
K
|
K
|
K
|
80 |
TM2 | |||||||||
S
|
R
|
M
|
T
|
F
|
F
|
V
|
T
|
Q
|
L
|
90 |
A
|
I
|
T
|
D
|
S
|
F
|
T
|
G
|
L
|
V
|
100 |
N
|
I
|
L
|
T
|
D
|
I
|
N
|
W
|
R
|
F
|
110 |
ECL1 | TM3 | ||||||||
T
|
G
|
D
|
F
|
T
|
A
|
P
|
D
|
L
|
V
|
120 |
C
|
R
|
V
|
V
|
R
|
Y
|
L
|
Q
|
V
|
V
|
130 |
L
|
L
|
Y
|
A
|
S
|
T
|
Y
|
V
|
L
|
V
|
140 |
S
|
L
|
S
|
I
|
D
|
R
|
Y
|
H
|
A
|
I
|
150 |
ICL2 | |||||||||
V
|
Y
|
P
|
M
|
K
|
F
|
L
|
Q
|
G
|
E
|
160 |
TM4 | |||||||||
K
|
Q
|
A
|
R
|
V
|
L
|
I
|
V
|
I
|
A
|
170 |
W
|
S
|
L
|
S
|
F
|
L
|
F
|
S
|
I
|
P
|
180 |
ECL2 | |||||||||
T
|
L
|
I
|
I
|
F
|
G
|
K
|
R
|
T
|
L
|
190 |
S
|
N
|
G
|
E
|
V
|
Q
|
C
|
W
|
A
|
L
|
200 |
TM5 | |||||||||
W
|
P
|
D
|
D
|
S
|
Y
|
W
|
T
|
P
|
Y
|
210 |
M
|
T
|
I
|
V
|
A
|
F
|
L
|
V
|
Y
|
F
|
220 |
I
|
P
|
L
|
T
|
I
|
I
|
S
|
I
|
M
|
Y
|
230 |
G
|
I
|
V
|
I
|
R
|
T
|
I
|
W
|
I
|
K
|
240 |
S
|
K
|
T
|
Y
|
E
|
T
|
V
|
I
|
S
|
N
|
250 |
ICL3 | |||||||||
C
|
S
|
D
|
G
|
K
|
L
|
C
|
S
|
S
|
Y
|
260 |
TM6 | |||||||||
N
|
R
|
G
|
L
|
I
|
S
|
K
|
A
|
K
|
I
|
270 |
K
|
A
|
I
|
K
|
Y
|
S
|
I
|
I
|
I
|
I
|
280 |
L
|
A
|
F
|
I
|
C
|
C
|
W
|
S
|
P
|
Y
|
290 |
F
|
L
|
F
|
D
|
I
|
L
|
D
|
N
|
F
|
N
|
300 |
ECL3 | TM7 | ||||||||
L
|
L
|
P
|
D
|
T
|
Q
|
E
|
R
|
F
|
Y
|
310 |
A
|
S
|
V
|
I
|
I
|
Q
|
N
|
L
|
P
|
A
|
320 |
L
|
N
|
S
|
A
|
I
|
N
|
P
|
L
|
I
|
Y
|
330 |
H8 | |||||||||
C
|
V
|
F
|
S
|
S
|
S
|
I
|
S
|
F
|
P
|
340 |
C
|
R
|
E
|
Q
|
R
|
S
|
Q
|
D
|
S
|
R
|
350 |
C-term | |||||||||
M
|
T
|
F
|
R
|
E
|
R
|
T
|
E
|
R
|
H
|
360 |
E
|
M
|
Q
|
I
|
L
|
S
|
K
|
P
|
E
|
F
|
370 |
I
|
DIAGRAMS
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
Pick color:
Invitro Mutant Data: Increased binding/potency: >5-fold, >10-fold; Reduced binding/potency: >5-fold, >10-fold; No/low effect (<5-fold); and N/A
MUTATIONS
PHYSIOLOGICAL LIGANDS
neuropeptide S
STRUCTURE MODELS
STRUCTURES
No structures available